Studies on eye irritation caused by chemicals in rabbits. 1. A quantitative structure-activity relationships approach to primary eye irritation of chemicals in rabbits.

Eye irritation hazard of chemicals and formulations assessed by methods in vitro.

BACKGROUND The aim of this study was to compare human and animal skin irritation data with results of selected in vitro methods, including HET-CAM test, Neutral Red Release Assay, Neutral Red Uptake Assay and EpiOcular eye irritation test and with already existing data of eye irritation obtained from animal experiments. METHODS Chemicals employed in previous skin irritation validation studies...

1 Subgroup 3 . Eye Irritation

In silico prediction of serious eye irritation or corrosion potential of chemicals

Rapidly and correctly identifying eye irritants or corrosive chemicals is an important issue in health hazard assessment. The purpose of this study is to describe the development of in silico methods for the classification of chemicals into irritants/corrosives or non-irritants/non-corrosives. A total of 5220 chemicals for a serious eye irritation (EI) dataset and 2299 chemicals as an eye corro...

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model.

To comply with the Seventh Amendment to the EU Cosmetics Directive and EU REACH legislation, validated non-animal alternative methods for reliable and accurate assessment of ocular toxicity in man are needed. To address this need, we have developed an eye irritation test (EIT) which utilizes a three dimensional reconstructed human cornea-like epithelial (RhCE) tissue model that is based on norm...

Application of Alternative Methods in the Regulatory Assessment of Chemical Safety Related to Human Eye Irritation & Severe Eye Irritation